Subject direction is based on whole genome and transcriptome analysis tumor identification bio - marker, transcriptome part has been completed, is now have 10 samples of genome-wide data, seven cancer, three corresponding carcinoma and 10 samples and the reference sequence alignment, there has been a SNP, CNV and other testing comments as a result, the aim is to filter the high frequency mutation, and the sample doesn't match, what is the relative variation, what to do or what to do the following analysis figure? Any reference of specific methods and literature can be recommended